|
KMID : 0043319990220050507
|
|
Archives of Pharmacal Research
1999 Volume.22 No. 5 p.507 ~ p.514
|
|
|
2- or 6-(1-Azidoalkyl)-5,8-Dimethoxy-1,4-Napyhthoquinone: Synthesis, Evaluation of Cytotoxic Activity, Antitumor Activity and Inhibitory Effect on DNA Topoisomerase-I
|
|
Chae Gyu-Han
Song Gyu-Yong
Kim Yong
Cho Hoon
Sok Dai-Eun
Ahn Byung-Zun
|
|
|
Abstract
|
|
|
|
6-(1-azidoalkyl)-DMNQ derivatives compared to 2-(1-azidoalkyl)-DMNQ isomers, exhibited higher cytotoxic activity against L1210 mouse leukemia cells and stronger inhibition of DNA topoisomerase-I (TOPO-I), suggesting involvement of steric hindrance. However, similar antitumor activity against mice bearing S-180 cell was shown by 2-an 6-(1-azidoalkyl)-DMNQ derivatives.
|
|
|
KEYWORD
|
|
|
Azidoalkylated naphthoquinones, DNA topoisomerase-I inhibition, Antitumor activity, Structure-activity relationship
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|